{"id":16649,"date":"2026-10-06T00:13:00","date_gmt":"2026-10-06T07:13:00","guid":{"rendered":"https:\/\/buenosdiasbcs.com\/?p=16649"},"modified":"2026-10-05T22:15:20","modified_gmt":"2026-10-06T05:15:20","slug":"obesidad-activa-mecanismo-especifico-que-altera-la-relajacion-del-corazon","status":"publish","type":"post","link":"https:\/\/buenosdiasbcs.com\/?p=16649","title":{"rendered":"Obesidad activa mecanismo espec\u00edfico que altera la relajaci\u00f3n del coraz\u00f3n"},"content":{"rendered":"\n<h2 id=\"h-la-insuficiencia-cardiaca-con-fraccion-de-eyeccion-preservada-representa-mas-de-la-mitad-de-los-casos-de-insuficiencia-cardiaca-y-se-estima-que-afecta-a-cerca-de-23-millones-de-personas\" class=\"wp-block-heading\">La insuficiencia cardiaca con fracci\u00f3n de eyecci\u00f3n preservada representa m\u00e1s de la mitad de los casos de insuficiencia cardiaca y se estima que afecta a cerca de 23 millones de personas<\/h2>\n\n\n\n<p class=\"wp-block-paragraph\">Un estudio liderado por el&nbsp;<a href=\"https:\/\/www.excelsior.com.mx\/temas\/ciencia\" target=\"_blank\" rel=\"noopener\">Centro Nacional de Investigaciones Cardiovasculares Carlos III (CNIC)<\/a>&nbsp;identific\u00f3 la activaci\u00f3n del receptor de glucocorticoides como un mecanismo causal de la disfunci\u00f3n diast\u00f3lica temprana asociada a la obesidad.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">El hallazgo, que se publica en la revista &#8216;Cardiovascular Research&#8217;, abre la puerta al desarrollo de tratamientos adaptados al origen molecular de esta forma de insuficiencia cardiaca.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">La insuficiencia cardiaca con fracci\u00f3n de eyecci\u00f3n preservada (HFpEF, por sus siglas en ingl\u00e9s) representa m\u00e1s de la mitad de los casos de insuficiencia cardiaca y se estima que afecta a cerca de 23 millones de personas en todo el mundo. En esta enfermedad, el coraz\u00f3n mantiene su capacidad de contracci\u00f3n, pero tiene dificultades para relajarse y llenarse correctamente de sangre.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Su aparici\u00f3n est\u00e1 estrechamente relacionada con trastornos como la obesidad,&nbsp;<a href=\"https:\/\/www.excelsior.com.mx\/temas\/hipertension\" target=\"_blank\" rel=\"noopener\">la hipertensi\u00f3n<\/a>&nbsp;arterial, la hiperglucemia o la apnea del sue\u00f1o. Dichas condiciones suelen coincidir en un mismo paciente, lo que ha dificultado determinar qu\u00e9 mecanismos activa cada una y por qu\u00e9 los tratamientos no ofrecen la misma respuesta en todos los casos.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">El trabajo, dirigido por Enrique Lara-Pezzi, l\u00edder del grupo de Regulaci\u00f3n Molecular de la Insuficiencia Cardiaca del CNIC, analiza por separado el efecto temprano de estas cuatro comorbilidades sobre el coraz\u00f3n.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Para ello, el equipo utiliz\u00f3 modelos murinos que reproduc\u00edan la evoluci\u00f3n de la enfermedad asociada al envejecimiento. Adem\u00e1s, se analiz\u00f3 el tejido cardiaco en las primeras fases de alteraci\u00f3n de la relajaci\u00f3n ventricular, antes de que se desarrollara una insuficiencia cardiaca.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Mediante secuenciaci\u00f3n de ARN de n\u00facleo \u00fanico, una tecnolog\u00eda que permite conocer la actividad de los genes en los distintos tipos celulares, los investigadores analizaron cerca de 50 mil n\u00facleos del ventr\u00edculo izquierdo.<\/p>\n\n\n\n<h3 id=\"h-la-obesidad-y-la-hiperglucemia-provocan-la-remodelacion-molecular-mas-intensa-y-extensa-con-cambios-en-distintos-tipos-de-celulas-presentes-en-el-corazon-cardiomiocitos-fibroblastos-celulas-endoteliales-y-macrofagos-explico-la-primera-autora-antonella-ausiello\" class=\"wp-block-heading\">La obesidad y la hiperglucemia provocan la remodelaci\u00f3n molecular m\u00e1s intensa y extensa, con cambios en distintos tipos de c\u00e9lulas presentes en el coraz\u00f3n: cardiomiocitos, fibroblastos, c\u00e9lulas endoteliales y macr\u00f3fagos&#8221;, explic\u00f3 la primera autora, Antonella Ausiello.<\/h3>\n\n\n\n<p class=\"wp-block-paragraph\">Asimismo, la hipertensi\u00f3n y la hipoxia intermitente cr\u00f3nica, utilizada para reproducir la apnea del sue\u00f1o, generaron modificaciones m\u00e1s moderadas.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">No obstante, a pesar de compartir algunos efectos, la obesidad y la hiperglucemia no da\u00f1an el coraz\u00f3n de la misma manera.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">As\u00ed, en los modelos de obesidad, el equipo identific\u00f3 a la activaci\u00f3n del receptor de glucocorticoides como uno de los principales mecanismos responsables del da\u00f1o cardiaco. Esta relaci\u00f3n causal se confirm\u00f3 mediante distintas estrategias de intervenci\u00f3n: tanto la reversi\u00f3n de la obesidad mediante un cambio de dieta como la inhibici\u00f3n directa del receptor, con el f\u00e1rmaco mifepristona o mediante sobreexpresi\u00f3n de la mol\u00e9cula GAS5, permitieron restaurar la funci\u00f3n cardiaca.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Estos resultados, se\u00f1alan los autores, indican que la activaci\u00f3n de este receptor constituye una diana terap\u00e9utica espec\u00edfica y modificable en la disfunci\u00f3n diast\u00f3lica asociada a la obesidad.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Sin embargo, en los modelos de hiperglucemia, la inhibici\u00f3n de esta misma v\u00eda no fue suficiente para restablecer la funci\u00f3n cardiaca, lo que pone de manifiesto que cada comorbilidad induce el da\u00f1o card\u00edaco a trav\u00e9s de mecanismos moleculares distintos y que, por tanto, &#8220;no existe una estrategia terap\u00e9utica \u00fanica aplicable a todos los pacientes&#8221;, asegur\u00f3 Lara-Pezzi.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Los autores consideran que los datos respaldan el desarrollo de estrategias de medicina estratificada, dirigidas al mecanismo molecular dominante en cada paciente.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Pese a ello, subrayan que los resultados se han obtenido en modelos experimentales y que ser\u00e1 necesario confirmarlos en muestras humanas y mediante estudios cl\u00ednicos antes de plantear su aplicaci\u00f3n terap\u00e9utica.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><\/p>\n","protected":false},"excerpt":{"rendered":"<p>La insuficiencia cardiaca con fracci\u00f3n de eyecci\u00f3n preservada representa m\u00e1s de la mitad de los casos de insuficiencia cardiaca y&#8230;<\/p>\n","protected":false},"author":2,"featured_media":16650,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[20],"tags":[],"class_list":["post-16649","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-salud"],"yoast_head":"<!-- This site is optimized with the Yoast SEO Premium plugin v26.8 (Yoast SEO v28.6) - 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